Key result
Right atrial pressure is modified by efferent parasympathetic neurons located in a region distinct from those controlling heart rate, as demonstrated by differential responses to SAP and CV stimulation.
Population
Open-chest anesthetized dogs with autonomically decentralized hearts
Comparison
Stimulation of the intracardiac parasympathetic… vs Stimulation of right and left cervical…
Design
Preclinical
Authors
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Caution against clinical translation; extends mapping of distinct parasympathetic pathways in canine models.
Efferent parasympathetic neurons controlling right atrial pressure are anatomically distinct from those controlling heart rate in the canine heart.
Inoue et al. (1994) studied this question. Stimulation of intracardiac parasympathetic nerves to the SA nodal area (SAP Stim) vs. Stimulation of right and left cervical vagosympathetic complexes (CV Stim) was evaluated on Right atrial pressure (a wave pressure) and its first pressure derivative (dP/dt). Right atrial pressure is modified by efferent parasympathetic neurons located in a region distinct from those controlling heart rate, as demonstrated by differential responses to SAP and CV stimulation.
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