Why the study?
Does RAGP ablation or blockade alter autonomic control of atrial rate in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Injection of hexamethonium or lidocaine into the… vs Baseline
Design
Preclinical
Authors
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RAGP ablation leaves prejunctional parasympathetic inhibition of sympathetic tachycardia intact in dogs; hypothesis-generating for selective autonomic targeting but should not yet change practice.
Does RAGP ablation or blockade alter autonomic control of atrial rate in anesthetized dogs?
Sinoatrial nodal parasympathectomy eliminates direct vagal control of the SA node while leaving prejunctional parasympathetic projections to sympathetic afferents intact.
McGuirt et al. (1997) studied this question.
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