Key result
Chronic parasympathetic stimulation via a cardiac neurostimulator effectively decreased ventricular rate during atrial fibrillation to 100-140 bpm over 1-2 years in dogs.
Why the study?
Does chronic parasympathetic stimulation of the right inferior ganglionated plexus reduce ventricular rate during atrial fibrillation in a canine model?
Population
9 mongrel dogs with induced atrial fibrillation (via rapid atrial pacing)
Design
Preclinical
Follow-up
1-2 years
Authors
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Provides long-term proof-of-concept in dogs; leaves open translation to human AF rate control.
Does chronic parasympathetic stimulation of the right inferior ganglionated plexus reduce ventricular rate during atrial fibrillation in a canine model?
Chronic parasympathetic stimulation of the right inferior ganglionated plexus via a transvenous neurostimulator is a feasible and effective method for ventricular rate control during atrial fibrillation in a canine model.
Mischke et al. (2009) studied Atrial Fibrillation (n=9). Chronic parasympathetic stimulation via a cardiac neurostimulator was evaluated on Feasibility of chronic parasympathetic stimulation for ventricular rate control during AF. Chronic parasympathetic stimulation via a cardiac neurostimulator effectively decreased ventricular rate during atrial fibrillation to 100-140 bpm over 1-2 years in dogs.
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