Key result
Neural stimulation of the inferior interatrial ganglionated plexus during AF demonstrated a linear correlation between R-R interval lengthening and stimulus voltage (R = 0.99; P < 0.001).
Why the study?
Does electrical stimulation of the inferior interatrial parasympathetic plexus at varying parameters affect ventricular rate during atrial fibrillation in a canine model?
Population
9 dogs with permanent epicardial bipolar screw-in electrodes fixed in the inferior interatrial ganglionated…
Design
Preclinical
Authors
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Supports device-based AF rate control feasibility; leaves open translation from canine model to human implants.
Does electrical stimulation of the inferior interatrial parasympathetic plexus at varying parameters affect ventricular rate during atrial fibrillation in a canine model?
p-value: p=<0.001
Energy and voltage requirements for cardiac neurostimulation to achieve significant negative dromotropic effects during atrial fibrillation are within the limits of conventional pacemakers, suggesting feasibility for chronic implantable devices.
Soós et al. (2005) studied Atrial fibrillation (n=9). Neural stimulation of the inferior interatrial ganglionated plexus was evaluated on R-R interval lengthening (p=<0.001). Neural stimulation of the inferior interatrial ganglionated plexus during AF demonstrated a linear correlation between R-R interval lengthening and stimulus voltage (R = 0.99; P < 0.001).
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