Key result
Neuronal tracing and electrical stimulation in dogs showed parasympathetic ganglia mediating sinoatrial function localize to the pulmonary vein fat pad, not the posterior atrial fat pad.
Why the study?
Does the pulmonary vein fat pad (PVFP) contain the primary ganglia mediating parasympathetic regulation of sinoatrial node function in the dog heart?
Population
Dog heart model
Comparison
Electrical stimulation of ventral right atrial… vs Electrical stimulation of dorsal right atrial…
Design
Preclinical
Follow-up
5-10 days (for retrograde transport)
Authors
Loading...
Challenges recent PVFP/IVC-ILA localizations; leaves open dominant parasympathetic site for clinical neuromodulation.
Does the pulmonary vein fat pad (PVFP) contain the primary ganglia mediating parasympathetic regulation of sinoatrial node function in the dog heart?
The pulmonary vein fat pad, rather than the posterior atrial fat pad, is the primary location of ganglia mediating parasympathetic regulation of sinoatrial node function in the dog heart.
Mick et al. (1992) studied Parasympathetic regulation of sinoatrial function. Electrical stimulation and neuronal marker injection was evaluated on Localization of parasympathetic ganglia. Neuronal tracing and electrical stimulation in dogs showed parasympathetic ganglia mediating sinoatrial function localize to the pulmonary vein fat pad, not the posterior atrial fat pad.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: