Key result
Higher serum levels of Ang 1-5 and the composite marker [Ang 1-7+Ang 1-5] independently predicted cardiovascular death or heart failure hospitalization in patients with HFpEF.
Why the study?
The renin-angiotensin system plays an important role in HF, but the role and effects of alternative renin-angiotensin system Angs on outcome in HF with preserved ejection fraction remained unestablished.
Do baseline levels of alternative renin-angiotensin system angiotensins predict cardiovascular death or HF hospitalization in patients with HFpEF?
Cohort (n=155)
No
Do baseline levels of alternative renin-angiotensin system angiotensins predict cardiovascular death or HF hospitalization in patients with HFpEF?
Ang 1-5 and the alternative renin-angiotensin system composite marker [Ang 1-7+Ang 1-5] are independent predictors of adverse outcomes in patients with HFpEF.
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May refine HFpEF risk stratification; leaves open whether Ang 1-5 levels should guide therapy.
Binder et al. (2019) conducted a cohort in Heart failure with preserved ejection fraction (n=155). Serum levels of Ang 1-7, Ang 1-5, and composite marker [Ang 1-7+Ang 1-5] was evaluated on Combined clinical end point of cardiovascular death or HF hospitalization. Higher serum levels of Ang 1-5 and the composite marker [Ang 1-7+Ang 1-5] independently predicted cardiovascular death or heart failure hospitalization in patients with HFpEF.
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