Key result
Elevated urinary angiotensinogen (>3.0 nmol AngI Eq/g Cre) was associated with an increased risk for deterioration of renal function in patients with chronic kidney disease (HR 3.52).
Why the study?
Does elevated urinary angiotensinogen predict the deterioration of renal function in patients with chronic kidney disease?
Population
80 patients with chronic kidney disease (CKD) not treated with AngII blocking agents.
Comparison
Measurement of urinary angiotensinogen. vs Patients with urinary angiotensinogen <3.0 nmol…
Design
Cohort
Follow-up
mean 23 months (maximum 43 months)
Authors
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Urinary angiotensinogen may mark intrarenal AngII activity in untreated CKD; leaves open its prognostic value pending validation.
Cohort (n=80)
Does elevated urinary angiotensinogen predict the deterioration of renal function in patients with chronic kidney disease?
Hazard Ratio: 3.52
Urinary angiotensinogen serves as a non-invasive marker of intrarenal AngII activity and independently predicts the deterioration of renal function in patients with chronic kidney disease.
Yamamoto et al. (2007) conducted a cohort in Chronic Kidney Disease (n=80). Elevated urinary angiotensinogen (>3.0 nmol AngI Eq/g Cre) vs. Urinary angiotensinogen <3.0 nmol AngI Eq/g Cre was evaluated on Deterioration of renal function (estimated GFR decline of >2.5 ml/min per yr) (HR 3.52). Elevated urinary angiotensinogen (>3.0 nmol AngI Eq/g Cre) was associated with an increased risk for deterioration of renal function in patients with chronic kidney disease (HR 3.52).
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