Baseline Urinary Angiotensinogen Excretion Predicts Deterioration of the Kidney Function in Patients with Chronic Kidney Disease

Figures

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  Figure 1.. Recruitment and enrollment of this study. We consecutively recruited 111 patients with chronic kidney disease (CKD) 20-80 years old who were admitted to our hospital and whose urinary angiotensinogen (AGT) excretion had been measured between January 2012 and December 2016. We excluded 25 patients with CKD whose estimated glomerular filtration rate (eGFR) was <15 mL/min/1.73 m2 (CKD stage 5). In addition, we excluded 24 patients with CKD whose one-year follow-up data were not available. Finally, we evaluated 62 patients with CKD in this study.

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  Figure 2.. The relationship between the annual change in the estimated glomerular filtration rate (eGFR) and baseline urinary angiotensinogen (AGT) excretion. The annual change in the eGFR was significantly and negatively correlated with the urinary AGT excretion (r=-0.31, p=0.015).

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  Figure 3.. The comparison of the annual change in the estimated glomerular filtration rate (eGFR) among quartiles according to the baseline urinary angiotensinogen (AGT) excretion. The patients were divided into the quartiles according to the baseline urinary AGT excretion, and the levels of annual change in the eGFR were compared among the quartiles. Box plots represent the 25th percentile, median, and 75th percentile of each group. Error bars denote the 10th and 90th percentiles. Groups were numbered from the lowest quartile of baseline urinary AGT excretion. Data are means±standard deviation. **p<0.01 Group 2 vs. Group 4. *p<0.05 Group 3 vs. Group 4.