Key result
Wistar fatty rats exhibited age-dependent increases in plasma angiotensinogen concentration and higher levels of cardiac and aortic angiotensinogen mRNA compared to lean controls.
Why the study?
Does the Wistar fatty rat model of obesity and hypertension exhibit altered tissue-specific angiotensinogen gene expression compared to lean controls?
Does the Wistar fatty rat model of obesity and hypertension exhibit altered tissue-specific angiotensinogen gene expression compared to lean controls?
Obesity-linked hypertension in this rat model is associated with tissue-specific increases in cardiac and aortic angiotensinogen gene expression.
No immediate clinical implications from rat data; leaves open angiotensinogen's role in human obesity hypertension.
Wistar fatty rats (WFR) show obesity and obesity-related features, including hypertension. In this study, we examined the expression of angiotensinogen mRNA in a variety of tissues at different times in WFR and control Wistar lean rats (WLR). WFR were obese and hypertensive at 16 and 24 wk. Plasma renin activity and plasma angiotensinogen concentration showed age-dependent increases in WFR but decreases in WLR. Northern blot analysis showed no significant differences in the levels of hepatic and renal angiotensinogen mRNA between WFR and WLR, and the levels of fat and adrenal angiotensinogen mRNA were lower in WFR than in WLR. On the other hand, the levels of cardiac angiotensinogen mRNA at 16 and 24 wk and those of aortic angiotensinogen mRNA at 16 wk were significantly higher in WFR than in WLR. These results show that the expression of tissue angiotensinogen mRNA is regulated differently in WFR and WLR and indicate that the development of hypertension in WFR is accompanied at least temporally with increases in plasma angiotensinogen concentration as well as in cardiac and aortic angiotensinogen mRNA. Moreover, these results suggest the existence of obesity hypertension-linked and tissue-specific regulation of angiotensinogen gene expression.
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Tamura et al. (1997) studied Obesity and hypertension. Obesity and hypertension (Wistar fatty rats) vs. Wistar lean rats (WLR) was evaluated on Expression of angiotensinogen mRNA in a variety of tissues. Wistar fatty rats exhibited age-dependent increases in plasma angiotensinogen concentration and higher levels of cardiac and aortic angiotensinogen mRNA compared to lean controls.
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