Key result
The maximum plasma concentration (Cmax) of the active H4 isomer of clopidogrel significantly correlated with ADP-induced platelet aggregation (r = -0.439, p = 0.025), serving as a potential marker for patient response to therapy.
Why the study?
Does the pharmacokinetic profile of clopidogrel metabolites correlate with antiplatelet response in patients with cardiovascular diseases?
Population
62 patients with cardiovascular diseases receiving either a single 300 mg loading dose of clopidogrel or a…
Design
Cohort
Authors
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May identify clopidogrel nonresponders via active metabolite Cmax; leaves open whether PK monitoring improves outcomes.
Observational (n=62)
No
Does the pharmacokinetic profile of clopidogrel metabolites correlate with antiplatelet response in patients with cardiovascular diseases?
Effect estimate: r = -0.439
p-value: p=0.025
The maximum plasma concentration of the active H4 isomer of clopidogrel correlates significantly with platelet aggregation, suggesting it could serve as a marker for patient response to therapy.
Karaźniewicz‐Łada et al. (2013) conducted an observational in Cardiovascular diseases (n=62). Clopidogrel was evaluated on Correlation between maximum plasma concentration (Cmax) of the active H4 isomer and platelet aggregation (r = -0.439, p=0.025). The maximum plasma concentration (Cmax) of the active H4 isomer of clopidogrel significantly correlated with ADP-induced platelet aggregation (r = -0.439, p = 0.025), serving as a potential marker for patient response to therapy.
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