Why the study?
Does measuring clopidogrel metabolite plasma concentrations identify poor compliance and variable metabolism in patients with peripheral arterial occlusive disease on clopidogrel?
Does measuring clopidogrel metabolite plasma concentrations identify poor compliance and variable metabolism in patients with peripheral arterial occlusive disease on clopidogrel?
Determining clopidogrel metabolite plasma concentrations can help identify poor compliance and variable metabolism, although most variability in platelet response is not caused by noncompliance.
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Metabolite testing may identify noncompliance in some clopidogrel non-responders; leaves open whether routine TDM improves outcomes in PAOD.
Mani et al. (2008) studied this question.
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