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January 1, 1995Journal of Clinical Oncology

Ciprofloxacin versus trimethoprim/sulfamethoxazole for prophylaxis of bacterial infections in bone marrow transplant recipients: a randomized, controlled trial.

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Authors

MLMichael A. LewAspenTech (United States)KKKathleen KehoeWestern Cape Department of HealthJRJustin RitzHarvard University

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Implication

Randomized trial compares ciprofloxacin and trimethoprim/sulfamethoxazole for infection prevention in bone marrow transplant recipients, suggesting both are safe and effective.

Key Points

  • To compare the efficacy and safety of ciprofloxacin and trimethoprim/sulfamethoxazole for preventing bacterial infections in bone marrow transplant patients.
  • Prospective, randomized, double-blinded, controlled trial
  • Enrolled 146 adult inpatients undergoing bone marrow transplantation for lymphoma, leukemia, or solid tumors
  • Ciprofloxacin (750 mg orally twice daily) was compared with trimethoprim/sulfamethoxazole (160 mg trimethoprim and 800 mg sulfamethoxazole orally twice daily) for prophylaxis.
  • No significant differences in fever occurrence or overall infection rates between groups (P=0.43).
  • TMS recipients had a higher incidence of Clostridium difficile enterocolitis (10 vs. 0 episodes, P=0.001).
  • Granulocytopenia lasted longer in TMS recipients compared to CIP recipients, P=0.08 for both comparisons.

Cite This Study

Lew et al. (1995) studied this question.

synapsesocial.com/papers/6a6a8be845e10bb5bcf2c017https://doi.org/10.1200/jco.1995.13.1.239
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Alpha-streptococcal septicemia in leukemic children treated with continuous or large dosage intermittent cytosine arabinoside1989 · 58 citations
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  3. 3Prevention of Infection by Trimethoprim-Sulfamethoxazole Plus Amphotericin B in Patients with Acute Nonlymphocytic Leukaemia1981 · 214 citations
  4. 4Prophylactic Trimethoprim-Sulfamethoxazole During Consolidation Chemotherapy for Acute Leukemia: A Controlled Trial1981 · 80 citations