What question did this study set out to answer?

To evaluate the efficacy and safety of oral ciprofloxacin prophylaxis in preventing bacterial infections during chemotherapy-induced prolonged neutropenia in bone marrow transplant recipients.

March 1, 1991Transplantation

Prophylaxis of Bacterial Infections With Ciprofloxacin in Patients Undergoing Bone Marrow Transplantation

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Authors

MLMichael A. LewAspenTech (United States)KKKathleen KehoeWestern Cape Department of Health JRJEROME RITZHarvard University

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Implication

Randomized double-blind trial demonstrates reduced bacterial infections in neutropenic bone marrow transplant recipients, indicating effective prophylaxis.

Key Points

To evaluate the efficacy and safety of oral ciprofloxacin prophylaxis in preventing bacterial infections during chemotherapy-induced prolonged neutropenia in bone marrow transplant recipients.
Prospective, randomized, double-blinded, placebo-controlled trial enrolling 26 oncology patients (25 undergoing bone marrow transplantation).
Patients received oral ciprofloxacin (750 mg twice daily; n=7 evaluable) or placebo (n=11 evaluable) starting within 48 hours of chemotherapy initiation until absolute granulocyte count reached ≥500/µL or fever onset (≥38.3 °C).
Documented bacterial infections occurred in 0 of 7 ciprofloxacin recipients compared to 10 infections (5 bacteremias, 4 skin/soft tissue, 1 urinary tract infection) in 11 placebo recipients (P = 0.0003).
Fever onset was delayed in the ciprofloxacin arm compared to placebo (median: 6 days vs. 3 days after granulocyte count dropped to ≤500/µL, P = 0.01).
Ciprofloxacin recipients required fewer days of therapeutic antimicrobials relative to placebo recipients (median: 28 antibiotic-days vs. 49, P < 0.02).

Cite This Study

Lew et al. (1991) studied this question.

synapsesocial.com/papers/6a7d16b9342883c6199ffda8 https://doi.org/10.1097/00007890-199103000-00017

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Implication

Randomized double-blind trial demonstrates reduced bacterial infections in neutropenic bone marrow transplant recipients, indicating effective prophylaxis.

Prophylaxis of Bacterial Infections With Ciprofloxacin in Patients Undergoing Bone Marrow Transplantation

Discussion

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Implication

Key Points

Cite This Study

Prophylaxis of Bacterial Infections With Ciprofloxacin in Patients Undergoing Bone Marrow Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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