Key result
A single ventricular extra-stimulus in conscious dogs induced a transient increase in cardiac metabolic demand, followed immediately by a 12% decrease in coronary vascular resistance index.
Why the study?
Does a single ventricular extra-activation induce compensatory coronary vasodilation in conscious dogs?
Population
8 conscious dogs with experimentally produced complete heart block, chronically implanted electromagnetic…
Comparison
A single ventricular extra-stimulus introduced… vs Control (baseline before the extra-stimulus)
Design
Preclinical
Authors
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Supports compensatory coronary vasodilation after ventricular extrasystoles in conscious dogs; hypothesis-generating for human coronary responses to arrhythmias.
Does a single ventricular extra-activation induce compensatory coronary vasodilation in conscious dogs?
Effect estimate: 12 +/- 2% decrease
A transient increase in cardiac metabolic demand from a single ventricular extra-activation is followed immediately by compensatory coronary vasodilation within the same cardiac cycle.
Schwartz et al. (1982) studied experimentally produced complete heart block (n=8). Single ventricular extra-stimulus vs. Control (preceding beats) was evaluated on Coronary vascular resistance index (12 +/- 2% decrease). A single ventricular extra-stimulus in conscious dogs induced a transient increase in cardiac metabolic demand, followed immediately by a 12% decrease in coronary vascular resistance index.
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