January 1, 1982Circulation ResearchOpen Access

Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog.

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Population

11 conscious dogs with experimentally produced complete heart block, chronically implanted electromagnetic…

Design

Preclinical

Authors

GSGregory G. SchwartzPreventive Cardiology PMP. A. McHaleDuke Medical Center JGJ. C. GreenfieldDurham VA Medical Center

Discussion

Member takes

Implication

Rapid coronary autoregulation to brief occlusions appears metabolically mediated in animals; leaves open human translation and clinical relevance.

Structured PICO

Population

11 conscious dogs with experimentally produced complete heart block, chronically implanted electromagnetic flow probes, and pneumatic occluders on the left circumflex coronary artery

Intervention

Diastolic coronary occlusions lasting 100 to 400 msec performed at paced heart rates of 40, 60, and 120 beats/min

Outcome

Reactive hyperemic response (coronary blood flow)surrogate

Autoregulation of coronary flow in response to brief diastolic occlusions is very rapid and likely mediated by a metabolic mechanism.

Cite This Study

Schwartz et al. (1982) studied this question.

synapsesocial.com/papers/6a8987c5755d28965dfd49d5 https://doi.org/10.1161/01.res.50.1.28

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Implication

Rapid coronary autoregulation to brief occlusions appears metabolically mediated in animals; leaves open human translation and clinical relevance.

Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hyperemic response of the coronary circulation to brief diastolic occlusion in the conscious dog.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider