Key result
Temporary restriction of arterial inflow after 8-second coronary occlusions in dogs markedly reduced the percent repayment of the flow deficit from 618% to 213% (P<0.0005).
Population
Conscious and anesthetized dogs
Comparison
Temporary restriction of arterial inflow after… vs Unrestricted reactive hyperemia after occlusion
Design
Preclinical
Authors
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Does not support clinical inflow restriction after occlusion; extends evidence for myogenic control of reactive hyperemia in animal models.
Absolute Event Rate: 213% vs 618%
p-value: p=< 0.0005
Restricting arterial inflow significantly reduces reactive hyperemia with minimal increase in duration, suggesting local mechanisms and myogenic responses are key drivers of hyperemia after brief coronary occlusions.
Eikens et al. (1974) studied this question. Temporary restriction of arterial inflow after 8-second occlusions vs. Unrestricted reactive hyperemia was evaluated on Percent repayment of the flow deficit (p=< 0.0005). Temporary restriction of arterial inflow after 8-second coronary occlusions in dogs markedly reduced the percent repayment of the flow deficit from 618% to 213% (P<0.0005).
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