Key result
Subendocardial ischemia occurred when endocardial to epicardial flow ratios fell below 1.0 (P<0.001) and was predictable from the ratio of oxygen supply to demand.
Why the study?
How do determinants of subendocardial oxygen delivery and oxygen demand interact to cause ischemia in an open chest dog model?
Population
Open chest dogs
Design
Preclinical
Authors
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Supports supply-demand ratio for predicting subendocardial ischemia in dogs; hypothesis-generating for human translation.
How do determinants of subendocardial oxygen delivery and oxygen demand interact to cause ischemia in an open chest dog model?
p-value: p=<0.001
Subendocardial ischemia can be predicted by the ratio of oxygen supply (DPTI x O2 content) to demand (TTI), which can be estimated from hemoglobin, saturation, and blood pressure.
Brazier et al. (1974) studied Subendocardial ischemia. Aortic stenosis and normovolemic anemia vs. Normal state was evaluated on Subendocardial ischemia (ST elevation on endocardial ECG) (p=<0.001). Subendocardial ischemia occurred when endocardial to epicardial flow ratios fell below 1.0 (P<0.001) and was predictable from the ratio of oxygen supply to demand.
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