Why the study?
What is the relationship between heart rate, aortic valve area, and subendocardial ischemia (estimated by oxygen supply/demand ratio) in children with valvar aortic stenosis?
Population
80 infants and children with isolated valvar aortic stenosis
Design
Cross-sectional
Authors
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Tachycardia may exacerbate ischemia in severe pediatric aortic stenosis; hypothesis-generating for rate-targeted interventions.
What is the relationship between heart rate, aortic valve area, and subendocardial ischemia (estimated by oxygen supply/demand ratio) in children with valvar aortic stenosis?
In children with severe valvar aortic stenosis, tachycardia significantly reduces the myocardial oxygen supply/demand ratio, suggesting exercise-induced tachycardia could help identify borderline ischemia.
Lewis et al. (1974) studied this question.
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