Review discusses calcium signaling pathways and their potential as treatment targets in ovarian cancer, suggesting new therapeutic strategies.
Ovarian cancer (OC) is a deadly disease. The poor prognosis and high lethality of OC are attributed to its high degrees of aggressiveness, resistance to chemotherapy and recurrence rates. Calcium ion (Ca²⁺) signaling has received attention in recent years, as it appears to form an essential part of various aspects of cancer pathophysiology and is a potential therapeutic target for OC treatment. Disruption of normal Ca²⁺ signaling pathways can induce changes in cell cycle progression, apoptosis, proliferation and migration and invasion, leading to the development of the malignant phenotype of tumors. In the present review, the main roles of ion channel/receptor/pump‑triggered Ca²⁺ signaling pathways located at the plasma membrane and organelle Ca²⁺ transport in OC are summarized. In addition, the potential of Ca²⁺ signaling as a novel target for the development of effective treatment strategies for OC was discussed. Furthering the understanding into the role of Ca²⁺ signaling in OC is expected to facilitated the identification of novel therapeutic targets and improved clinical outcomes for patients.
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Deng et al. (2023) studied this question.
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