Why the study?
Does blockade of T-type Ca2+ channels inhibit proliferation of human ovarian cancer cells?
Does blockade of T-type Ca2+ channels inhibit proliferation of human ovarian cancer cells?
Blockade of T-type Ca2+ channels inhibits human ovarian cancer cell proliferation and tumor formation in vivo, suggesting a potential therapeutic target.
T-type Ca2+ channel blockade merits investigation in ovarian cancer; hypothesis-generating from animal data, no clinical implications yet.
Regulation of Ca(2+) channels has been implicated in the progression of tumor cells. We report here that T-type Ca(2+) channel expression in human ovarian cancer tissues is greatly increased compared to normal ovarian tissues. Blockade of T-type Ca(2+) channel with NNC 55-0396, mibefradil, or by specifically knocking down the expression of these proteins with siRNA-Ca(v)3.1/3.2 suppressed the proliferation of two ovarian cancer cell lines and increased G0/G1 phase distribution in the cell cycle. Furthermore, NNC 55-0396 slowed ovarian cancer formation in nude mice. Therefore the function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells.
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Li et al. (2011) studied this question.
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