Key result
A histidine-to-alanine mutation at position 510 (H510A) in the PA subunit of influenza A virus abolished transcriptional endonuclease activity while maintaining viral RNA replication.
Population
Influenza A virus RNA-dependent RNA polymerase (influenza A/WSN/33 virus)
Comparison
Mutation of evolutionarily conserved amino acids… vs Wild-type RNA polymerase
Design
Preclinical
Authors
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PA function remains incompletely defined; leaves open targeted mechanistic and antiviral research.
The PA subunit of the influenza A virus RNA polymerase is required for viral RNA transcription, specifically through its endonuclease activity, which is abolished by the H510A mutation.
Fodor et al. (2002) studied Influenza A virus. H510A mutation in the PA subunit was evaluated on Transcription and replication of viral RNA. A histidine-to-alanine mutation at position 510 (H510A) in the PA subunit of influenza A virus abolished transcriptional endonuclease activity while maintaining viral RNA replication.
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