Population
Madin-Darby canine kidney cells infected with wild-type influenza virus strain A/WSN/33 or the…
Comparison
Temperature shift to nonpermissive temperature… vs Permissive temperature (34°C) and wild-type virus
Design
Preclinical
Authors
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No immediate clinical implications for influenza therapy; extends mechanistic insights into PA-mediated polymerase assembly in temperature-sensitive mutants.
The PA subunit of the influenza virus RNA polymerase is involved in the assembly of functional viral RNA polymerase complexes from their inactive intermediates.
Kawaguchi et al. (2004) studied this question.
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