Population
Cells expressing GFP-tagged influenza A virus RNA polymerase subunits
Comparison
Coexpression of PA subunit with PB1 subunit vs Individual expression of PB1 subunit
Design
Preclinical
Authors
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Supports PB1-PA co-transport model in influenza polymerase; leaves open validation as antiviral target in human infection models.
The PA subunit is required for efficient nuclear accumulation of the PB1 subunit in the influenza A virus RNA polymerase complex.
Fodor et al. (2004) studied this question.
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