Population
YP1N clones in which the PB1 and NP genes can be expressed in response to dexamethasone
Design
Preclinical
Authors
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May inform subunit-selective influenza antivirals; leaves open validation in mammalian systems.
The PB1 subunit alone catalyzes cRNA synthesis, while the PA subunit acts as a modulator required for vRNA synthesis in influenza virus replication.
Nakagawa et al. (1996) studied this question.
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