February 1, 1995Journal of VirologyOpen Access

The RNA polymerase PB2 subunit is not required for replication of the influenza virus genome but is involved in capped mRNA synthesis

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Population

clone 64 cell line (expressing RNA polymerase PB1, PA, and NP genes but not PB2 upon dexamethasone induction)

Design

Preclinical

Authors

Discussion

May guide selective antiviral targeting of PB2; leaves open translation from animal models to human efficacy.

Population

clone 64 cell line (expressing RNA polymerase PB1, PA, and NP genes but not PB2 upon dexamethasone induction)

Intervention

Dexamethasone induction and transfection with chimeric NS-CAT RNAs

Outcome

Replication of influenza virus genome and synthesis of capped mRNA

The study demonstrates that the influenza virus PB2 subunit is specifically required for capped mRNA synthesis but not for genome replication.

Nakagawa et al. (1995) studied this question.

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