Population
In vitro system using purified recombinant influenza virus polymerase complexes, nucleocapsid protein, and…
Design
Preclinical
Authors
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Does not alter influenza therapies; leaves open NP-polymerase interaction as a hypothesis-generating antiviral target.
The study demonstrates that the RNA-binding activity of influenza A virus nucleocapsid protein is not required for unprimed viral RNA replication, suggesting a direct interaction with the viral polymerase mediates this process.
Newcomb et al. (2008) studied this question.
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