Key result
T-type Ca2+ current can trigger Ca2+ release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes, albeit less efficiently than L-type Ca2+ current.
T-type Ca2+ channels can trigger sarcoplasmic reticulum Ca2+ release in ventricular myocytes, but less efficiently than L-type channels, supporting the privileged role of L-type channels in excitation-contraction coupling.
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T-type Ca2+ entry may trigger SR release in isolated myocytes; leaves open physiological role in intact hearts.
SIPIDO et al. (1998) studied this question. T-type Ca2+ current vs. L-type Ca2+ current was evaluated on Ca2+ release from the sarcoplasmic reticulum. T-type Ca2+ current can trigger Ca2+ release from the sarcoplasmic reticulum in guinea-pig ventricular myocytes, albeit less efficiently than L-type Ca2+ current.