December 1, 1997Circulation Research
Low Efficiency of Ca 2+ Entry Through the Na + -Ca 2+ Exchanger as Trigger for Ca 2+ Release From the Sarcoplasmic Reticulum
Population
Single guinea pig ventricular myocytes
Comparison
Ca2+ entry through reverse-mode Na-Ca2+ exchange vs Ca2+ entry through L-type Ca2+ current (ICaL)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Indicates limited physiological role for reverse-mode NCX in Ca2+ triggering; leaves open relevance in disease models or human myocytes.
Structured PICO
P
Population
Single guinea pig ventricular myocytes
I
Intervention
Ca2+ entry through reverse-mode Na(+)-Ca2+ exchange (isolated using 20 mumol/L nisoldipine)
C
Comparator
Ca2+ entry through L-type Ca2+ current (ICaL)
O
Outcome
Characteristics of Ca2+ release from the sarcoplasmic reticulum (trigger efficiency, delay, and magnitude)surrogate
Reverse-mode Na+-Ca2+ exchange has low efficiency and significant delay in triggering sarcoplasmic reticulum Ca2+ release compared to L-type Ca2+ channels, indicating a negligible physiological role during the action potential.
Cite This Study
Sipido et al. (1997) studied this question.