Key result
Islet-1 is a novel marker of the adult sinoatrial node, and Islet-1(+) cells were not detected in the infarct zone after myocardial infarction, providing no evidence for them as cardiac progenitors.
Population
Adult murine heart and human sinoatrial node tissue
Comparison
Myocardial infarction vs Healthy adult murine heart
Design
Preclinical
Follow-up
2 to 28 days post-myocardial infarction
Authors
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Islet-1 marks adult SAN but not post-MI progenitors in mice; challenges its progenitor role and leaves open adult cardiac regeneration sources.
Islet-1 identifies the adult sinoatrial node rather than serving as a marker for adult cardiac progenitor cells, even following myocardial infarction.
Weinberger et al. (2012) studied Myocardial infarction. Myocardial infarction vs. Healthy hearts was evaluated on Distribution and identity of Islet-1(+) cells. Islet-1 is a novel marker of the adult sinoatrial node, and Islet-1(+) cells were not detected in the infarct zone after myocardial infarction, providing no evidence for them as cardiac progenitors.
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