Key result
Activation of Notch signaling in the developing murine myocardium produced fully penetrant accessory pathways and ventricular preexcitation, whereas Notch inhibition resulted in a hypoplastic AV node and loss of physiologic AV conduction delay.
Why the study?
Does Notch signaling regulate atrioventricular conduction and the formation of accessory pathways in developing murine myocardium?
Population
Mice (developing myocardium)
Design
Preclinical
Authors
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Notch modulates murine AV conduction development; leaves open its role in human accessory pathways pending further validation.
Does Notch signaling regulate atrioventricular conduction and the formation of accessory pathways in developing murine myocardium?
Absolute Event Rate: 16% vs 30%
p-value: p=<0.01
Notch signaling plays a critical role in the functional maturation of the embryonic AV canal myocardium, and its dysregulation can lead to ventricular preexcitation and accessory pathways.
Rentschler et al. (2011) studied Wolff-Parkinson-White syndrome / Ventricular preexcitation. Tissue-specific Notch signaling activation (NICD) or inhibition (DNMAML) vs. Littermate controls was evaluated on AV node volume indexed to heart weight (10^6 μm3/g) (p=<0.01). Activation of Notch signaling in the developing murine myocardium produced fully penetrant accessory pathways and ventricular preexcitation, whereas Notch inhibition resulted in a hypoplastic AV node and loss of physiologic AV conduction delay.
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