Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 7, 2014Circulation ResearchOpen Access

Loss of myocardial canonical Wnt signaling causes tricuspid atresia and hypoplastic right ventricle, while ectopic activation induces ectopic AV junction-like tissue; stabilizing β-catenin rescues Notch-mediated ventricular pre-excitation.

View Full Paper
Ask AI
Bookmark
Share

Population

Preclinical genetic model using a novel allele of β-catenin that preserves cell adhesive functions but…

Comparison

Modulation of canonical Wnt signaling and… vs Control/wild-type state (implied)

Design

Preclinical

Authors

BGBenjamin S. GillersACAditi ChiplunkarHAHaytham Aly

Discussion

Loading...

Member takes

Overview

Animal models link Wnt to AV maturation and pre-excitation; leaves open translation to human congenital heart disease or WPW.

Structured PICO

P
Population
Preclinical genetic model using a novel allele of β-catenin that preserves cell adhesive functions but disrupts canonical Wnt signaling
I
Intervention
Modulation of canonical Wnt signaling (loss of function, ectopic activation, and stabilization of β-catenin) and postnatal activation of Notch signaling
C
Comparator
Control/wild-type state (implied)
O
Outcome
Atrioventricular canal (AVC) maturation, morphological patterning, gene expression, and electrophysiological propertiessurrogate

Myocardial canonical Wnt signaling is a crucial regulator of atrioventricular canal maturation and electrical programming, providing mechanistic insights into congenital heart disease and Wolff-Parkinson-White syndrome.

Cite This Study

Gillers et al. (2014) studied this question.

synapsesocial.com/papers/6a70edfd87f921057127fadchttps://doi.org/10.1161/circresaha.116.304731
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Wnt/β-catenin signaling enables developmental transitions during valvulogenesis2016 · 52 citations
  2. 2Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways2011 · 101 citations
  3. 3Wnt/β-catenin pathway in arrhythmogenic cardiomyopathy2017 · 65 citations
  4. 4Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression2009 · 79 citations
  5. 5Petri Net modelling approach for analysing the behaviour of <b> <i>Wnt/</i> </b> <b> <i>‐catenin</i> </b> and <b> <i>Wnt/</i> </b> <i> Ca <sup>2+</sup> </i> signalling pathways in arrhythmogenic right ventricular cardiomyopathy2020 · 6 citations