Why the study?
Arrhythmogenic right ventricular cardiomyopathy causes myocyte loss and fibro fatty replacement, and modelling the Wnt/beta-catenin and Wnt/Ca2+ pathways may improve comprehension of the disease and its treatment regimen.
Design
Stochastic Petri net computational modelling study
Authors
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Modeling of Wnt pathways in ARVC adipogenesis is hypothesis-generating; leaves open targeted interventions pending experimental validation.
Stochastic petri net modeling of Wnt signaling pathways provides mechanistic insights into adipogenesis and apoptosis in arrhythmogenic right ventricular cardiomyopathy.
Azim et al. (2020) studied this question.
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