Population
Cultured chicken embryo aortic valves and mice with PeriostinCre-mediated tissue-restricted loss of…
Comparison
Loss of Wnt/β-catenin signaling vs Normal Wnt/β-catenin signaling
Design
Preclinical
Key result
Loss of β-catenin in valvular interstitial cells leads to aberrant chondrogenic nodules and increased nuclear expression of Sox9 and chondrogenic extracellular matrix proteins.
Authors
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No immediate clinical implications for myxomatous valve disease; leaves open β-catenin-Sox9 axis as therapeutic target pending human validation.
β-Catenin limits Sox9 nuclear localization and inhibits chondrogenic differentiation during valve development and in adult aortic valve homeostasis, providing mechanistic insights into myxomatous valve disease.
Fang et al. (2014) studied Heart valve disease. Loss of β-catenin was evaluated on Sox9 nuclear localization and chondrogenic extracellular matrix gene expression. Loss of β-catenin in valvular interstitial cells leads to aberrant chondrogenic nodules and increased nuclear expression of Sox9 and chondrogenic extracellular matrix proteins.