Key result
Inhibition of Notch signaling accelerated aortic valve calcification in vitro, a process that was attenuated by the addition of Sox9, demonstrating a Sox9-dependent mechanism.
Why the study?
Does inhibition of Notch signaling accelerate calcification in aortic valve interstitial cells?
Does inhibition of Notch signaling accelerate calcification in aortic valve interstitial cells?
Loss of Notch signaling contributes to aortic valve calcification via a Sox9-dependent mechanism, providing a potential molecular target for calcific aortic valve disease.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for Notch-Sox9 modulation of valve calcification; leaves open relevance to human disease progression or therapy.
Acharya et al. (2011) studied Calcific Aortic Valve Disease (n=7). Notch signaling inhibition (DAPT) vs. DMSO (vehicle control) was evaluated on Aortic valve calcification and Sox9 expression. Inhibition of Notch signaling accelerated aortic valve calcification in vitro, a process that was attenuated by the addition of Sox9, demonstrating a Sox9-dependent mechanism.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: