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September 23, 2025Open Access

Endothelial Notch signaling as a target for aortic valve calcification

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Authors

DEDaria EvensenABAnna BelyaevaДСД М Сердюкова

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Overview

This study demonstrates how Notch signaling influences osteogenic differentiation in aortic valve cells, suggesting new treatment avenues for calcific aortic valve disease.

Key Points

  • Activating Notch in endothelial cells increases osteogenic differentiation when co-cultured with interstitial cells.
  • Dysregulated Notch signaling in endothelial cells from calcific aortic valve disease patients enhances osteogenic differentiation.
  • Inhibiting Notch activity suppresses osteogenic differentiation indicating its regulatory role.
  • This work highlights Notch signaling as a potential therapeutic target for aortic valve calcification.

Cite This Study

Evensen et al. (2025) studied this question.

synapsesocial.com/papers/68d473bb31b076d99fa6cc43https://doi.org/10.21203/rs.3.rs-7535820/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibitory Role of Notch1 in Calcific Aortic Valve Disease2011 · 113 citations
  2. 2Notch1 Mutation Leads to Valvular Calcification Through Enhanced Myofibroblast Mechanotransduction2015 · 56 citations
  3. 3Notch1 suppression by microRNA-34a: a new mechanism of calcific aortic valve disease2019 · 7 citations
  4. 4Notch1 Promotes the Pro-Osteogenic Response of Human Aortic Valve Interstitial Cells via Modulation of ERK1/2 and Nuclear Factor-κB Activation2013 · 78 citations
  5. 5Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis2014 · 10 citations