Key result
This editorial highlights that microRNA-34a suppresses Notch1 expression to promote calcific aortic valve disease, presenting a novel pathogenic mechanism and potential therapeutic target.
Why the study?
Early signals prompting quiescent valve interstitial cells to transition to disease-associated phenotypes in calcific aortic valve disease remain unknown, and though NOTCH1 mutations cause calcification, such mutations are very rare.
Design
Editorial
Authors
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miR-34a inhibition may offer a CAVD drug target; hypothesis-generating in mice and leaves open human translation.
This editorial highlights the discovery that miR-34a suppresses Notch1 expression to promote calcific aortic valve disease, suggesting that targeting miR-34a or downstream pathways could offer novel pharmacological treatments for CAVD.
Raddatz et al. (2019) conducted an editorial in Calcific aortic valve disease. microRNA-34a inhibition was evaluated. This editorial highlights that microRNA-34a suppresses Notch1 expression to promote calcific aortic valve disease, presenting a novel pathogenic mechanism and potential therapeutic target.
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