Key result
Cadherin-11 knockdown abrogated calcific nodule formation in valvular myofibroblasts, indicating its necessity for generating intercellular tension during dystrophic calcification.
Why the study?
Does cadherin-11 regulate cell-cell tension and calcific nodule formation in aortic valve interstitial cells?
Population
Porcine aortic valve interstitial cells (AVICs) and human calcified leaflets
Comparison
Transforming growth factor β1 treatment, MEK1/2… vs Control/untreated cells
Design
Preclinical
Authors
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Cadherin-11 merits testing as a target in animal models of aortic stenosis; leaves open translation to human valve disease.
Does cadherin-11 regulate cell-cell tension and calcific nodule formation in aortic valve interstitial cells?
Cadherin-11 is essential for generating the intercellular tension required for dystrophic calcific nodule formation in aortic valve interstitial cells.
Hutcheson et al. (2012) studied Dystrophic calcific nodule formation. Cadherin-11 knockdown (siRNA) and MEK1/2 inhibition was evaluated on Calcific nodule formation. Cadherin-11 knockdown abrogated calcific nodule formation in valvular myofibroblasts, indicating its necessity for generating intercellular tension during dystrophic calcification.
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