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January 1, 2016DevelopmentOpen Access

Canonical Wnt signaling is required for EMT in the proximal outflow tract but not atrioventricular canal cushions, and Axin2 deletion leads to larger valves.

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Population

Transgenic mouse system with chemically inducible overexpression of Dkk1 and mice lacking Axin2

Design

Preclinical

Authors

FBFernanda M. BosadaVDVidusha DevasthaliKJKimberly Jones

Discussion

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Overview

Hypothesis-generating for region-specific Wnt roles in valvulogenesis; leaves open applicability to human congenital valve defects.

Structured PICO

P
Population
Transgenic mouse system with chemically inducible overexpression of Dkk1 and mice lacking Axin2
I
Intervention
Spatiotemporal inhibition of Wnt/β-catenin signaling via Dkk1 overexpression, and Axin2 deletion
O
Outcome
Endocardial-to-mesenchymal transformation (EMT) and valve formation/extracellular matrix patterningsurrogate

Wnt/β-catenin signaling is essential for specific developmental transitions during valvulogenesis, providing mechanistic insights into congenital valve defects.

Cite This Study

Bosada et al. (2016) studied this question.

synapsesocial.com/papers/6a8a6f1a1e528df4f2ec736dhttps://doi.org/10.1242/dev.130575
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis2013 · 76 citations
  2. 2Canonical Wnt Signaling Regulates Atrioventricular Junction Programming and Electrophysiological Properties2014 · 100 citations
  3. 3Loss of β-Catenin Promotes Chondrogenic Differentiation of Aortic Valve Interstitial Cells2014 · 60 citations
  4. 4Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease2016 · 61 citations
  5. 5Increased canonical WNT/β-catenin signalling and myxomatous valve disease2016 · 8 citations