Population
Mice (developing endocardial cushions and valves)
Design
Preclinical
Authors
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Identifies Tbx20-Wnt axis in mouse valve maturation; leaves open translation to human congenital valve pathogenesis.
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion maturation and valve elongation during mouse cardiogenesis, providing insights into the etiology of congenital valve defects.
Cai et al. (2013) studied this question.
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