Population
Murine models (Tbx20-null embryos and Tbx20 heterozygous mutant mice)
Comparison
Gene targeting resulting in loss of Tbx20 or… vs Wild-type mice (implied)
Design
Preclinical
Authors
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Tbx20 is essential for cardiac morphogenesis and adult function in mice; leaves open its role in human congenital heart disease and cardiomyopathies.
Tbx20 is a critical transcriptional repressor essential for embryonic heart chamber differentiation and adult cardiac function, highlighting its potential role in congenital heart disease and cardiomyopathies.
Stennard et al. (2005) studied this question.
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