Population
Mouse embryos with targeted mutagenesis of Tbx2
Comparison
Homozygous Tbx2 null mutation vs Heterozygous Tbx2 mutation
Design
Preclinical
Follow-up
Evaluated at 9.5 days post coitus (dpc)
Authors
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Tbx2 is essential for AV canal and OFT patterning in mice; leaves open its role in human congenital heart defects.
Tbx2 plays a crucial role in embryonic heart development, specifically in patterning the atrioventricular canal and outflow tract morphogenesis.
Harrelson et al. (2004) studied this question.
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