Key result
Intravenous administration of Anacardium occidentale extract produced a significant dose-dependent decrease in mean arterial blood pressure in normotensive rabbits, up to an 89% reduction at 167 mg/kg.
Why the study?
Does Anacardium occidentale extract induce hypotensive and cardio-inhibitory effects in animal models?
Does Anacardium occidentale extract induce hypotensive and cardio-inhibitory effects in animal models?
Effect estimate: 89% decrease
Absolute Event Rate: 8% vs 73%
p-value: p=<0.001
Anacardium occidentale bark extract demonstrates strong hypotensive and cardio-inhibitory effects in animal models, providing a physiological basis for its traditional use in treating hypertension.
Marked hypotension in rabbits should not change practice; leaves open translational research on Anacardium occidentale.
Anacardium occidentale Linn. (Anacardiaceae) is a plant largely used in Africa for the treatment of different diseases. In Côte d'Ivoire it's commonly used for the treatment of hypertension. The present study was carried out in order to assess the effects of Anacardium occidentale extract (ANOE) on cardiovascular parameters in animal models. A mercury manometer kymograph of Ludwig was used to measure the blood pressure of normotensive rabbits in control conditions (normal physiological solution) and under the influence of ANOE. The contractile activity of an isolated rat heart was also measured in control conditions and under the influence of ANOE in different physiological media using a modified Langendhorff (1895) apparatus. The aqueous Anacardium occidentale (ANOE) bark extract applied intravenously in different doses (12, 40, 90, and 167 mg/kg b.w.), produced a significant dose-dependent decrease in blood pressure of previously normotensive rabbits (up to 89% vs control). Atropine (1 mg/ml) pre-treatment failed to reverse the hypotensive effects elicited by the extract. ANOE applied to isolated rat heart preparations in different concentrations (0.01, 0.1, 1.0, and 10 µg/ml) induced negative inotropic and chronotropic effects. Atropine pre-treatment of heart preparations (0.1 µg/ml) failed to reverse the negative effects induced by ANOE. The extract's action on heart contractile activity studied in modified culture media further confirmed its cardio-inhibitory effects. ANOE induced strong hypotensive and cardio-inhibitory effects in animal models.
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Tchikaya et al. (2011) studied Normotensive (experimental animal models). Anacardium occidentale extract (ANOE) vs. Control conditions (normal physiological solution / baseline) was evaluated on Mean arterial blood pressure (MABP) in rabbits (89% decrease, p=<0.001). Intravenous administration of Anacardium occidentale extract produced a significant dose-dependent decrease in mean arterial blood pressure in normotensive rabbits, up to an 89% reduction at 167 mg/kg.
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