Key result
The PFA-100 closure time normalized in all type 1 von Willebrand disease patients after desmopressin infusion, providing a rapid tool to discriminate between good and non-responders.
Why the study?
Does the Platelet Function Analyzer PFA-100 accurately evaluate the response to desmopressin or VWF concentrates in patients with von Willebrand disease?
Observational (n=41)
Does the Platelet Function Analyzer PFA-100 accurately evaluate the response to desmopressin or VWF concentrates in patients with von Willebrand disease?
The PFA-100 closure time is a simple and rapid tool to discriminate between good and non-responders to desmopressin in patients with von Willebrand disease.
No takes yet. Share an insight, caveat, or question.
May enable rapid desmopressin response assessment in type 1 vWD; leaves open prospective validation before routine adoption.
Fressinaud et al. (1999) conducted an observational in von Willebrand disease (n=41). Desmopressin or von Willebrand factor concentrates vs. Baseline (before infusion) was evaluated on Closure time with the PFA-100 using ADP and epinephrine cartridges, VWF ristocetin cofactor activity, and bleeding time. The PFA-100 closure time normalized in all type 1 von Willebrand disease patients after desmopressin infusion, providing a rapid tool to discriminate between good and non-responders.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: