Key result
Aspirin increased template bleeding time by 61% and PFA-100 closure time by 79% compared to placebo, with the PFA-100 producing less variable effects and fewer false positive results.
Why the study?
Does aspirin affect closure time measured by PFA-100 compared to template bleeding time in healthy volunteers?
Population
12 healthy volunteers
Comparison
Aspirin 750 mg three times a day for 5 days vs Placebo three times a day for 5 days
Design
RCT, randomized crossover design, double-blind
Follow-up
5 days per treatment period
Authors
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PFA-100 may be preferred over template bleeding time for aspirin monitoring; confirms superior reproducibility in RCT evaluation.
RCT (n=12)
double-blind
randomized
Does aspirin affect closure time measured by PFA-100 compared to template bleeding time in healthy volunteers?
The PFA-100 closure time is as sensitive as the template bleeding time for detecting aspirin's effect on platelet function, but with less variability and fewer false positives.
Marshall et al. (1997) conducted an RCT in healthy volunteers (n=12). aspirin vs. placebo was evaluated on platelet function measured by template bleeding time and PFA-100 closure time. Aspirin increased template bleeding time by 61% and PFA-100 closure time by 79% compared to placebo, with the PFA-100 producing less variable effects and fewer false positive results.
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