August 10, 2002Swiss Medical WeeklyOpen Access

Evaluation of a Platelet Function Analyser (PFA-100) in patients with a bleeding tendency

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Why the study?

Does the PFA-100 improve the detection of primary haemostasis abnormalities compared to bleeding time in patients with suspected bleeding disorders?

Population

113 subjects (70 healthy subjects and 43 patients with a suspected mild bleeding disorder)

Comparison

Platelet function testing using the PFA-100 device vs Bleeding time (BT) determination

Design

Cross-sectional

Discussion

Member takes

Implication

PFA-100 may improve ASA detection sensitivity over bleeding time; leaves open whether it should replace bleeding time in practice.

Structured PICO

Does the PFA-100 improve the detection of primary haemostasis abnormalities compared to bleeding time in patients with suspected bleeding disorders?

Population

113 subjects (70 healthy subjects and 43 patients with a suspected mild bleeding disorder)

Intervention

Platelet function testing using the PFA-100 device (measuring closure time with EPI and ADP)

Comparator

Bleeding time (BT) determination

Outcome

Diagnostic performance (sensitivity and specificity) for detecting von Willebrand disease and acetylsalicylic acid ingestionsurrogate

The PFA-100 is a simple, less invasive, and more sensitive in vitro alternative to bleeding time for evaluating primary hemostasis abnormalities such as ASA intake and von Willebrand disease.

Limitations

Special citrated whole blood has to be processed within 0.5 to 4 h after sampling
Duplicate measurements are necessary
Results differ between blood sampled in the morning or in the afternoon

Cite This Study

A 2002 study studied this question.

synapsesocial.com/papers/6a83faf6a3cef8348e997e7f https://doi.org/10.4414/smw.2002.10039

Topics

Dual antiplatelet therapy

View Full Paper

Ask AI

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August 10, 2002Swiss Medical WeeklyOpen Access

Evaluation of a Platelet Function Analyser (PFA-100) in patients with a bleeding tendency

View Full Paper

Ask AI

Bookmark

Why the study?

Does the PFA-100 improve the detection of primary haemostasis abnormalities compared to bleeding time in patients with suspected bleeding disorders?

Population

113 subjects (70 healthy subjects and 43 patients with a suspected mild bleeding disorder)

Comparison

Platelet function testing using the PFA-100 device vs Bleeding time (BT) determination

Design

Cross-sectional

Discussion

Member takes

Implication

PFA-100 may improve ASA detection sensitivity over bleeding time; leaves open whether it should replace bleeding time in practice.

Structured PICO

Does the PFA-100 improve the detection of primary haemostasis abnormalities compared to bleeding time in patients with suspected bleeding disorders?

Population

113 subjects (70 healthy subjects and 43 patients with a suspected mild bleeding disorder)

Intervention

Platelet function testing using the PFA-100 device (measuring closure time with EPI and ADP)

Comparator

Bleeding time (BT) determination

Outcome

Diagnostic performance (sensitivity and specificity) for detecting von Willebrand disease and acetylsalicylic acid ingestionsurrogate

The PFA-100 is a simple, less invasive, and more sensitive in vitro alternative to bleeding time for evaluating primary hemostasis abnormalities such as ASA intake and von Willebrand disease.

Limitations

Special citrated whole blood has to be processed within 0.5 to 4 h after sampling
Duplicate measurements are necessary
Results differ between blood sampled in the morning or in the afternoon

Cite This Study

A 2002 study studied this question.

synapsesocial.com/papers/6a83faf6a3cef8348e997e7f https://doi.org/10.4414/smw.2002.10039

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Dual antiplatelet therapy

View Full Paper

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