Why the study?
Does the Platelet Function Analyzer (PFA)-100 test substitute for the template bleeding time as a screening test for platelet dysfunction in hospital inpatients?
Does the Platelet Function Analyzer (PFA)-100 test substitute for the template bleeding time as a screening test for platelet dysfunction in hospital inpatients?
The PFA-100 test reflects platelet function better than the bleeding time and is more sensitive to aspirin-induced platelet dysfunction, suggesting it could replace the bleeding time as a first-line screening test.
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PFA-100 aligned with aggregation testing more often than bleeding time in discordants; leaves open substitution as first-line screening pending validation.
Francis et al. (1999) studied this question.
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