Key result
The PFA-100 system successfully detects platelet abnormalities caused by impaired vWF or inhibited glycoprotein receptors.
The PFA-100 system provides a rapid, quantitative in vitro measure of platelet function sensitive to adherence and aggregation abnormalities.
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Supports PFA-100 evaluation in research models; leaves open clinical adoption pending human validation.
Kundu et al. (2023) studied Platelet dysfunction. PFA-100 system was evaluated on Closure time. The PFA-100 system, an in vitro device measuring platelet function via closure time, successfully detected abnormalities caused by impaired von Willebrand factor or inhibited glycoprotein receptors.
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