Why the study?
Can the PFA-100 system detect defects in platelet adhesion or aggregation in vitro?
Population
Normal blood samples (in vitro)
Comparison
Incubation with antibodies to glycoprotein Ib… vs Normal blood samples without antibodies or with…
Design
Preclinical
Authors
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PFA-100 detects specific platelet defects in vitro; leaves open clinical screening utility pending human validation.
Can the PFA-100 system detect defects in platelet adhesion or aggregation in vitro?
The PFA-100 system can rapidly detect defects in platelet adhesion and aggregation in vitro, making it a potentially useful tool for screening platelet dysfunction.
Kundu et al. (1996) studied this question.
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