Key result
In diet-induced obese mice, arterial stiffness developed within 1 month and preceded the onset of hypertension by 5 months, returning to normal with weight loss.
Why the study?
Does arterial stiffness precede the development of hypertension in diet-induced obesity?
Population
Diet-induced obese mice
Design
Preclinical
Follow-up
6 months
Authors
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No immediate clinical implications from mouse data; leaves open whether arterial stiffness precedes hypertension in humans.
Does arterial stiffness precede the development of hypertension in diet-induced obesity?
In a diet-induced obesity mouse model, arterial stiffness precedes the development of hypertension, supporting the hypothesis that stiffness is a cause rather than a consequence of hypertension.
Weisbrod et al. (2013) studied Diet-induced obesity. Diet-induced obesity was evaluated on Development of arterial stiffness and hypertension. In diet-induced obese mice, arterial stiffness developed within 1 month and preceded the onset of hypertension by 5 months, returning to normal with weight loss.
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