Key result
Participants in the highest quartile of urine albumin-creatinine ratio had a higher risk of developing hypertension compared with the lowest quartile (adjusted OR 1.93, P=0.006).
Why the study?
Does higher urinary albumin excretion predict incident hypertension and blood pressure progression in nonhypertensive individuals without diabetes?
Cohort (n=1,499)
Does higher urinary albumin excretion predict incident hypertension and blood pressure progression in nonhypertensive individuals without diabetes?
Odds Ratio: 1.93
p-value: p=0.006
Low-grade albuminuria, even below the conventional threshold for microalbuminuria, independently predicts the development of hypertension and blood pressure progression in nondiabetic individuals.
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May flag preclinical hypertension risk; hypothesis-generating for microalbuminuria screening, with prospective trials needed before practice change.
Wang et al. (2005) conducted a cohort in nonhypertensive individuals without diabetes (n=1,499). Highest urine albumin-creatinine ratio (UACR) quartile vs. Lowest UACR quartile was evaluated on incident hypertension (OR 1.93, p=0.006). Participants in the highest quartile of urine albumin-creatinine ratio had a higher risk of developing hypertension compared with the lowest quartile (adjusted OR 1.93, P=0.006).
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